The The Impact of COVID-19 Pandemic on Cognitive Function in Older Adults with Dementia: A Systematic Review
Keywords:
COVID-19, cognitive function, dementia, elderlyAbstract
Background: The prevalence of dementia rises with the increasing life expectancy and elderly population. Due to the COVID-19 pandemic, it is challenging for caregivers to help carry out their daily activities and provide cognitive stimulants to slow down the deterioration. Therefore, this research aims to determine the impact of the COVID-19 pandemic on cognitive function in older people with dementia.
Methods: This systematic review sought and reviewed observational studies data taken from various databases such as PubMed, EBSCOHost, Google Scholar, and ScienceDirect starting from January to November 2022—using COVID-19, dementia, cognitive function, and elderly along with their synonyms as keywords.
Results: As many as 11 literatures with a total of 3132 participants were obtained to be reviewed. Ten out of 11 pieces of literature showed a deterioration in the cognitive function of older people with dementia due to the COVID-19 pandemic. In comparison, one piece of literature showed an improvement in cognitive function that was not significant.
Conclusion: The cognitive function of older people with dementia appears to deteriorate when compared between before and after the COVID-19 pandemic. This can be seen as a decrease in MMSE, MoCA, or both scoring results. However, due to confounding variables not being accounted for in the pieces of literature reviewed, it is impossible to pinpoint the Covid-19 pandemic as the exact reason for this deterioration.
References
Sinclair DA. Lifespan: why we age – and why we don’t have to. Ed ke-2. Amerika Serikat: Atria Books; 2019.
Hou Y, Dan X, Babbar M, Wei Y, Hasselbalch SG, Croteau DL, et al. Ageing as a risk factor for neurodegenerative disease. National Center for Biotechnology Information 2019; 15:565-81.
Jiawei Z. Cognitive functions of the brain: perception, attention, and memory. Cornell University 2019; 6:2-33.
Halidi R, Novianty D. Studi: angka penderita demensia capai 4 juta jiwa pada 2050. eJournal Kedokteran Indonesia 2018; 2:2-12.
Emmandy PD, Tadi P. Dementia. Ed ke-4. Amerika Serikat: StatPearls Publishing LLC; 2022.
Tousi B. Dementia care in the time of COVID-19 pandemic. National Center for Biotechnology 2020; 76:475-79.
Lestari F. Pengalaman Indonesia dalam menangani wabah COVID-19. Ed ke-1. Indonesia: Badan Nasional Penanggulangan Bencana; 2020.
Wang L, He W, Yu X, Hu D, Bao M, Liu H, et al. Coronavirus disease 2019 in elderly patients: characteristics and prognostic factors based on 4-week follow up. National Center for Biotechnology Information 2020; 80:639-45.
Suárez-González A, Rajagopalan J, Livingston G, Alladi S. The effect of COVID-19 isolation measures on the cognition and mental health of people living with dementia: a rapid systematic review of one year of evidence. medRXiv 2021; 1:8-10.
Rainero I, Bruni AC, Marra C, Cagnin A, Bonanni L, Cupidi C, et al. The impact of COVID-19 quarantine on patients with dementia and family caregivers: a nation-wide survey. National Center for Biotechnology Information 2021; 12:3-13.
Gan J, Liu S, Wu H, Chen Z, Fei M, Xu J, et al. The impact of the COVID-19 pandemic on Alzheimer's disease and other dementias. National Center for Biotechnology Information 2021; 10:1-8.
Khadka S. Study quality assessment tools. Ed ke-2. Inggris: SAGE Publications; 2020.
Ismail II, Kamel WA, Al-Hashel JY. Association of COVID-19 pandemic and rate of cognitive decline in patients with dementia and mild cognitive impairment: a cross-sectional study. SAGE journals 2021; 7:23-30.
Wei G, Diehl-Schmid J, Matias-Guiu JA, Pijnenburg Y, Landin-Romero R, Bogaardt H, et al. The effects of the COVID-19 pandemic on neuropsychiatric symptoms in dementia and carer mental health: an international multicentre study. Scientific Reports 2022; 12:2418.
Vislapuu M, Angeles RC, Berge LI, Kjerstad E, Gedde MH, Husebo BS. The consequences of COVID-19 lockdown for formal and informal resource utilization among home-dwelling people with dementia: results from the prospective pandem study. BioMed Central 2021; 21:1003.
Smith CR, Cullen B, Sheridan MP, Cavanagh J, Grosset KA, Grosset DG. Cognitive impairment in parkinson’s disease is multifactorial: a neuropsychological study. National Center for Biotechnology Information 2020; 141:500-8.
Tsapanou A, Papatriantafyllou JD, Yiannopoulou K, Sali D, Kalligerou F, Ntanasi E, et al. The impact of COVID-19 pandemic on people with mild cognitive impairment/dementia and on their caregivers. National Center for Biotechnology Information 2020; 36:583-87.
Torboli D, Mioni G, Busse C, Cagnin A, Vallesi A. Subjective experience of time in dementia with lewy bodies during COVID-19 lockdown. Springer Link 2021; 182:25-34.
Sorbara M, Graviotto HG, Lage-Ruiz GM, Turizo-Rodriguez CM, Sotelo-Lopez LA, Serra A, et al. COVID-19 and the forgotten pandemic: follow-up of neurocognitive disorders during lockdown in argentina. ScienceDirect 2021; 36:9-15.
Kazawa K, Kubo T, Akishita M, Ishii S. Long-term impact of the COVID-19 pandemic on facility and home-dwelling people dementia: perspectives from professionals involved in dementia care. Wiley Online Library 2022; 22:832-38.
Chen Z-C, Liu S, Gan J, Ma L, Du X, Zhu H, et al. The impact of the COVID-19 pandemic and lockdown on mild cognitive impairment, alzheimer’s disease and dementia with lewy bodies in china: a 1-year follow-up study. Frontiers 2021; 12:711658.
Manca R, De Marco M, Colston A, Raymont V, Amin J, Davies R, et al. The impact of social isolation due to COVID-19 on symptom progression in people with dementia: findings of the solitude study. Frontiers 2022; 13:877595.
Houben S, Bonnechere, B. The impact of COVID-19 infection on cognitive function and the implication for rehabilitation: a systematic review and meta-analysis. National Center for Biotechnology Information 2022; 13:7748.
Lee SH, Kim YB. Which type of social activities may reduce cognitive decline in the elderly?: a longitudinal population-based study. National Center for Biotechnology Information 2017; 16:165.
Sroykham W, Wongsawat Y. Effects of brain activity, morning salivary cortisol, and emotion regulation on cognitive impairment in elderly people. National Center for Biotechnology Information 2019; 98:26.
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